Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury.
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| Title: | Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury. |
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| Authors: | Chen Z; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China., Xie J; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China., Wu C; School of Medicine, Nankai University, Tianjin, China., Ye K; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China., Chen Y; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China., Song Y; Department of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China., Ma H; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China., Wu J; Laboratory Animal Research Center, Xiamen University, Xiameng, 361000, China., Chen L; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn., Xu Y; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China. xuyanfang99@hotmail.com.; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 27; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08794-y |
