Lactic acid promotes metastasis of papillary thyroid carcinoma by enhancing CPT1A lactylation.

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Title: Lactic acid promotes metastasis of papillary thyroid carcinoma by enhancing CPT1A lactylation.
Authors: Zhao M; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China., Han H; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China., Sun M; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China., Li R; Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China., Chen H; The Ninth Medical Center of the Chinese PLA General Hospital, Beijing, 100020, China., Liu F; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China., Miao C; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China., Wu Y; Department of Cell Biology, School of Basic Medical Sciences, Cheeloo Medical College of Medicine, Shandong University, Jinan, 250012, China., Shi X; Department of Cell Biology, School of Basic Medical Sciences, Cheeloo Medical College of Medicine, Shandong University, Jinan, 250012, China., Wu M; Department of Cell Biology, School of Basic Medical Sciences, Cheeloo Medical College of Medicine, Shandong University, Jinan, 250012, China., Materazzi G; Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, 56124, Pisa, Italy., Miccoli P; Department of Surgical, Medical, and Molecular Pathology and Critical Area, University of Pisa, 56124, Pisa, Italy., Lu J; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. 201262005933@email.sdu.edu.cn., Yue X; Department of Cell Biology, School of Basic Medical Sciences, Cheeloo Medical College of Medicine, Shandong University, Jinan, 250012, China. yuexu@sdu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 27; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08790-2