Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems.

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Title: Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems.
Authors: Pradhan B; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Kumar ST; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; National Centre for Cell Science, Pune, India., Wagner J; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany., Gallardo R; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Orlando G; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Laboratory of Pathogens and Host Immunity, University of Montpellier, CNRS and INSERM, Montpellier, France., De Vleeschouwer M; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Zorzini V; VIB Center for Neuroscience Leuven, Biophysics Technology Unit, Herestraat 49, Leuven, Belgium., Madine J; Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Louros N; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern Medical centre, Dallas, Texas, USA., Neher JJ; Biomedical Center (BMC), Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany.; Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Rousseau F; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium. frederic.rousseau@kuleuven.be.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. frederic.rousseau@kuleuven.be., Schymkowitz J; Switch Laboratory, VIB Center for Neuroscience Leuven, Leuven, Belgium. joost.schymkowitz@kuleuven.be.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. joost.schymkowitz@kuleuven.be.
Source: Nature communications [Nat Commun] 2026 Apr 28; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72515-4