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DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation.

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Title: DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation.
Authors: Niven J; College of Medicine and Health, University of Birmingham, Birmingham, UK., Kucuk S; College of Medicine and Health, University of Birmingham, Birmingham, UK., Gope A; College of Medicine and Health, University of Birmingham, Birmingham, UK., Certo M; College of Medicine and Health, University of Birmingham, Birmingham, UK., Cassidy FC; Human Health Institute, Maynooth University, Kildare, Ireland.; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Arana Echarri A; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UK., Ali S; College of Medicine and Health, University of Birmingham, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Ladoukakis E; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Barts and the London School of Medicine, Queen Mary University of London, London, UK., Vidali S; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Barts and the London School of Medicine, Queen Mary University of London, London, UK., Macchi C; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università Degli Studi di Milano, Milan, Italy., Amir SS; College of Medicine and Health, University of Birmingham, Birmingham, UK., Bergin R; Human Health Institute, Maynooth University, Kildare, Ireland., Davies S; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UK., Perkin OJ; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UK., Smith J; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.; Reaction Biology Europe GmbH, Freiburg, Germany., Cucchi D; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.; ADC Therapeutics UK (Ltd), London, UK., Heneghan H; Human Health Institute, Maynooth University, Kildare, Ireland., Wijesinghe S; College of Medicine and Health, University of Birmingham, Birmingham, UK., Jenkins BJ; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Baig S; College of Medicine and Health, University of Birmingham, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Mahony C; College of Medicine and Health, University of Birmingham, Birmingham, UK., Chidomere C; College of Medicine and Health, University of Birmingham, Birmingham, UK.; Charles River Laboratories, Portishead, Bristol, UK., Sarkar S; College of Medicine and Health, University of Birmingham, Birmingham, UK., Nicolaou A; Laboratory for Lipidomics and Lipid Biology, Division of Pharmacy and Optometry, School of Health Sciences, The University of Manchester, Manchester, UK.; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Caamaño J; College of Medicine and Health, University of Birmingham, Birmingham, UK., Croft A; College of Medicine and Health, University of Birmingham, Birmingham, UK., Davies E; Royal Orthopaedic Hospital, Birmingham, UK., Thompson D; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UK., O'Shea D; Human Health Institute, Maynooth University, Kildare, Ireland.; Department of Endocrinology, St. Vincent's University Hospital & University College Dublin, Dublin, Ireland., Jones SW; College of Medicine and Health, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Centre (Women's Metabolic Health Theme; Sarcopenia and Multimorbidity Theme), Birmingham, UK., Duggal NA; College of Medicine and Health, University of Birmingham, Birmingham, UK., Ruscica M; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università Degli Studi di Milano, Milan, Italy.; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Makarova M; College of Medicine and Health, University of Birmingham, Birmingham, UK., Jones N; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK., Da Silva Xavier G; College of Medicine and Health, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Centre (Women's Metabolic Health Theme; Sarcopenia and Multimorbidity Theme), Birmingham, UK., Geberhiwot T; College of Medicine and Health, University of Birmingham, Birmingham, UK.; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Turner JE; Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UK.; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK., Hogan AE; Human Health Institute, Maynooth University, Kildare, Ireland., Nedjai B; Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Barts and the London School of Medicine, Queen Mary University of London, London, UK., Mauro C; College of Medicine and Health, University of Birmingham, Birmingham, UK. c.mauro@bham.ac.uk.; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK. c.mauro@bham.ac.uk.; NIHR Birmingham Biomedical Research Centre (Women's Metabolic Health Theme; Sarcopenia and Multimorbidity Theme), Birmingham, UK. c.mauro@bham.ac.uk.
Source: EMBO reports [EMBO Rep] 2026 Jun; Vol. 27 (11), pp. 3120-3152. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1469-3178
DOI:10.1038/s44319-026-00765-w