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Protocol of a mixed (Retrospective and Prospective) longitudinal observational study of amiodarone for chronic Chagas cardiomyopathy (AMIO-CHAGAS study): Investigating immunomodulatory and trypanocidal effects.

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Title: Protocol of a mixed (Retrospective and Prospective) longitudinal observational study of amiodarone for chronic Chagas cardiomyopathy (AMIO-CHAGAS study): Investigating immunomodulatory and trypanocidal effects.
Authors: Barbosa JMC; Cell Biology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Faier-Pereira A; Platform of Molecular Analysis, Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Hasslocher-Moreno AM; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Costa AR; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Pereira ENGDS; Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Mendes FSNS; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., da Silva GMS; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Sangenis LHC; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Holanda MT; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Mediano MFF; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Saraiva RM; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Xavier SS; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Moreira ODC; Platform of Molecular Analysis, Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Daliry A; Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Veloso HH; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil., Salomão K; Cell Biology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
Source: PloS one [PLoS One] 2026 Apr 28; Vol. 21 (4), pp. e0347305. Date of Electronic Publication: 2026 Apr 28 (Print Publication: 2026).
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protocol of a mixed (Retrospective and Prospective) longitudinal observational study of amiodarone for chronic Chagas cardiomyopathy (AMIO-CHAGAS study): Investigating immunomodulatory and trypanocidal effects.
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  Data: <searchLink fieldCode="AU" term="%22Barbosa+JMC%22">Barbosa JMC</searchLink>; Cell Biology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Faier-Pereira+A%22">Faier-Pereira A</searchLink>; Platform of Molecular Analysis, Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Hasslocher-Moreno+AM%22">Hasslocher-Moreno AM</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+AR%22">Costa AR</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+ENGDS%22">Pereira ENGDS</searchLink>; Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendes+FSNS%22">Mendes FSNS</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+GMS%22">da Silva GMS</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Sangenis+LHC%22">Sangenis LHC</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Holanda+MT%22">Holanda MT</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Mediano+MFF%22">Mediano MFF</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Saraiva+RM%22">Saraiva RM</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Xavier+SS%22">Xavier SS</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Moreira+ODC%22">Moreira ODC</searchLink>; Platform of Molecular Analysis, Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Daliry+A%22">Daliry A</searchLink>; Laboratory of Clinical and Experimental Physiopathology, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Veloso+HH%22">Veloso HH</searchLink>; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Salomão+K%22">Salomão K</searchLink>; Cell Biology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Apr 28; Vol. 21 (4), pp. e0347305. <i>Date of Electronic Publication: </i>2026 Apr 28 (<i>Print Publication: </i>2026).
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