Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.
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| Title: | Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design. |
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| Authors: | Wang Q; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; State Key Laboratory of Chemical Biology, Chinese Academy of Sciences, Shanghai 201203, China., Chen M; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China., Lasram A; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany., Vihuri S; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Chou AZ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China., Bian W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 101408, China., Dai Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 101408, China., Haapanen O; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Enkavi G; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Pollmann C; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany., Vattulainen I; Department of Physics, University of Helsinki, Helsinki 00014, Finland., Cai T; Institute of Quantum Sensing, Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310027, China., Piehler J; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück 49076, Germany., Chou JJ; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; State Key Laboratory of Chemical Biology, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 101408, China. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 05; Vol. 123 (18), pp. e2601748123. Date of Electronic Publication: 2026 Apr 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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