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Noninvasive Urine Test Predicts Grade Group Upgrading in Patients on Active Surveillance for Prostate Cancer: Prospective Multisite Validation and Comparison with MRI.

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Title: Noninvasive Urine Test Predicts Grade Group Upgrading in Patients on Active Surveillance for Prostate Cancer: Prospective Multisite Validation and Comparison with MRI.
Authors: Tosoian JJ; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee., Meyers JI; Lynx Dx, Ann Arbor, Michigan., Moore B; Lynx Dx, Ann Arbor, Michigan., Britton CJ; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Chevli K; Western New York Urology Associates, Cheektowaga, New York., Rayford W; The Urology Group, Memphis, Tennessee., Gadzinski AJ; Comprehensive Urology, Royal Oak, Michigan., Joseph JV; Department of Urology, University of Rochester Medical Center, Rochester, New York., Patel P; Arizona State Urological Institute (ASUI) and Arizona State Urological Research Institute (ASURI), Gilbert, Arizona., Kasraeian A; Kasraeian Urology, Jacksonville, Florida., Sethi PS; Golden State Urology, Sacramento, California., Robinson HS; Geisinger Medical Center, Department of Urology, Danville, Pennsylvania., Assani KD; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Rings V; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Pierce J; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Scarpato KR; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Moses KA; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee., Barocas DA; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee., Chang SS; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee., Penson DF; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee., Sanda MG; Department of Urology, Emory University School of Medicine, Atlanta, Georgia., Ross AE; Northwestern University Department of Urology, Chicago, Illinois., Cooperberg MR; University of California San Francisco Departments of Urology and Epidemiology & Biostatistics, San Francisco, California., Salari K; Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Liss M; Department of Urology, UC San Diego Health, San Diego, California., Zhang Y; Department of Pathology, University of Michigan, Ann Arbor, Michigan., Siddiqui J; Department of Pathology, University of Michigan, Ann Arbor, Michigan., Singhal U; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan., Salami SS; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan., Morgan TM; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan., Palapattu GS; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan., Wei JT; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan., Cao J; Lynx Dx, Ann Arbor, Michigan., Bala V; Lynx Dx, Ann Arbor, Michigan., Oh Y; Lynx Dx, Ann Arbor, Michigan., Heaton S; Lynx Dx, Ann Arbor, Michigan., Zheng Y; Fred Hutchinson Cancer Research Center., Chinnaiyan AM; Rogel Cancer Center, Ann Arbor, Michigan.; Departments of Pathology and Urology, University of Michigan, Ann Arbor, Michigan.; Howard Hughes Medical Institute, Chevy Chase, Maryland.
Source: The Journal of urology [J Urol] 2026 May 20, pp. 101097JU0000000000005095. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0376374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3792 (Electronic) Linking ISSN: 00225347 NLM ISO Abbreviation: J Urol Subsets: MEDLINE
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  Data: Noninvasive Urine Test Predicts Grade Group Upgrading in Patients on Active Surveillance for Prostate Cancer: Prospective Multisite Validation and Comparison with MRI.
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  Data: <searchLink fieldCode="AU" term="%22Tosoian+JJ%22">Tosoian JJ</searchLink>; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Meyers+JI%22">Meyers JI</searchLink>; Lynx Dx, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Moore+B%22">Moore B</searchLink>; Lynx Dx, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Britton+CJ%22">Britton CJ</searchLink>; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chevli+K%22">Chevli K</searchLink>; Western New York Urology Associates, Cheektowaga, New York.<br /><searchLink fieldCode="AU" term="%22Rayford+W%22">Rayford W</searchLink>; The Urology Group, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Gadzinski+AJ%22">Gadzinski AJ</searchLink>; Comprehensive Urology, Royal Oak, Michigan.<br /><searchLink fieldCode="AU" term="%22Joseph+JV%22">Joseph JV</searchLink>; Department of Urology, University of Rochester Medical Center, Rochester, New York.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Arizona State Urological Institute (ASUI) and Arizona State Urological Research Institute (ASURI), Gilbert, Arizona.<br /><searchLink fieldCode="AU" term="%22Kasraeian+A%22">Kasraeian A</searchLink>; Kasraeian Urology, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Sethi+PS%22">Sethi PS</searchLink>; Golden State Urology, Sacramento, California.<br /><searchLink fieldCode="AU" term="%22Robinson+HS%22">Robinson HS</searchLink>; Geisinger Medical Center, Department of Urology, Danville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Assani+KD%22">Assani KD</searchLink>; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Rings+V%22">Rings V</searchLink>; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Pierce+J%22">Pierce J</searchLink>; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Scarpato+KR%22">Scarpato KR</searchLink>; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Moses+KA%22">Moses KA</searchLink>; Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Barocas+DA%22">Barocas DA</searchLink>; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chang+SS%22">Chang SS</searchLink>; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Penson+DF%22">Penson DF</searchLink>; Department of Urology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Sanda+MG%22">Sanda MG</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Ross+AE%22">Ross AE</searchLink>; Northwestern University Department of Urology, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Cooperberg+MR%22">Cooperberg MR</searchLink>; University of California San Francisco Departments of Urology and Epidemiology & Biostatistics, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Salari+K%22">Salari K</searchLink>; Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Liss+M%22">Liss M</searchLink>; Department of Urology, UC San Diego Health, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Pathology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Siddiqui+J%22">Siddiqui J</searchLink>; Department of Pathology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Singhal+U%22">Singhal U</searchLink>; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Salami+SS%22">Salami SS</searchLink>; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Morgan+TM%22">Morgan TM</searchLink>; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Palapattu+GS%22">Palapattu GS</searchLink>; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Wei+JT%22">Wei JT</searchLink>; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Lynx Dx, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Bala+V%22">Bala V</searchLink>; Lynx Dx, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Oh+Y%22">Oh Y</searchLink>; Lynx Dx, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Heaton+S%22">Heaton S</searchLink>; Lynx Dx, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Fred Hutchinson Cancer Research Center.<br /><searchLink fieldCode="AU" term="%22Chinnaiyan+AM%22">Chinnaiyan AM</searchLink>; Rogel Cancer Center, Ann Arbor, Michigan.; Departments of Pathology and Urology, University of Michigan, Ann Arbor, Michigan.; Howard Hughes Medical Institute, Chevy Chase, Maryland.
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  Data: <searchLink fieldCode="JN" term="%220376374%22">The Journal of urology</searchLink> [J Urol] 2026 May 20, pp. 101097JU0000000000005095. <i>Date of Electronic Publication: </i>2026 May 20.
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