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DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance.

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Title: DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance.
Authors: Khalife F; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Muzotte E; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Naji F; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Mahfouf W; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Izotte J; Animalerie A2, University of Bordeaux, Bordeaux, France., Pinson B; Metabolic Analyses Service, TBMCore-Université de Bordeaux-CNRS UAR 3427-INSERM, US005, Bordeaux, France., Claverol S; Univ. Bordeaux, Bordeaux Proteome, Bordeaux, France., Amoedo N; Inserm U1211 Maladies Rares: Génétique et Métabolisme (MRGM), Université de Bordeaux, Bordeaux, France.; CELLOMET, Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France., Fayyad-Kazan H; Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Lebanon., Dousset L; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France., Rossignol R; Inserm U1211 Maladies Rares: Génétique et Métabolisme (MRGM), Université de Bordeaux, Bordeaux, France.; CELLOMET, Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France., Rezvani HR; Univ. Bordeaux, Inserm, BRIC, UMR 1312, Bordeaux, France. hamid-reza.rezvani@u-bordeaux.fr.
Source: Cell death & disease [Cell Death Dis] 2026 Apr 28; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08815-w