Technical and biological sources of noise confound multiplexed enhancer AAV screening.

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Title: Technical and biological sources of noise confound multiplexed enhancer AAV screening.
Authors: Hunker AC; Allen Institute for Brain Science, Seattle, WA, USA. avery.hunker@alleninstitute.org., Mich JK; Allen Institute for Brain Science, Seattle, WA, USA. johnmi@alleninstitute.org., Taskin N; Allen Institute for Brain Science, Seattle, WA, USA., Torkelson A; Allen Institute for Brain Science, Seattle, WA, USA., Cardenas T; Allen Institute for Brain Science, Seattle, WA, USA., Lalanne JB; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Mahoney JT; Allen Institute for Brain Science, Seattle, WA, USA., Bertagnolli D; Allen Institute for Brain Science, Seattle, WA, USA., Chakka AB; Allen Institute for Brain Science, Seattle, WA, USA., Chakrabarty R; Allen Institute for Brain Science, Seattle, WA, USA., Donadio NP; Allen Institute for Brain Science, Seattle, WA, USA., Ferrer R; Allen Institute for Brain Science, Seattle, WA, USA., Gasperini M; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Goldy J; Allen Institute for Brain Science, Seattle, WA, USA., Guzman J; Allen Institute for Brain Science, Seattle, WA, USA., Jin K; Allen Institute for Brain Science, Seattle, WA, USA., Khem S; Allen Institute for Brain Science, Seattle, WA, USA., Kutsal R; Allen Institute for Brain Science, Seattle, WA, USA., Martinez RA; Allen Institute for Brain Science, Seattle, WA, USA., Newman D; Allen Institute for Brain Science, Seattle, WA, USA., Pena N; Allen Institute for Brain Science, Seattle, WA, USA., Rimorin C; Allen Institute for Brain Science, Seattle, WA, USA., Rocha D; Allen Institute for Brain Science, Seattle, WA, USA., Shapovalova NV; Allen Institute for Brain Science, Seattle, WA, USA., Tieu M; Allen Institute for Brain Science, Seattle, WA, USA., Weed N; Allen Institute for Brain Science, Seattle, WA, USA., Zhou T; Allen Institute for Brain Science, Seattle, WA, USA., Hodge R; Allen Institute for Brain Science, Seattle, WA, USA., Yao S; Allen Institute for Brain Science, Seattle, WA, USA., Shendure J; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA.; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA., Smith KA; Allen Institute for Brain Science, Seattle, WA, USA., Lein ES; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Neurological Surgery, University of Washington, Seattle, WA, USA., Tasic B; Allen Institute for Brain Science, Seattle, WA, USA., Levi BP; Allen Institute for Brain Science, Seattle, WA, USA., Ting JT; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Neurobiology & Biophysics, University of Washington, Seattle, WA, USA.; Washington National Biomedical Research Center, Seattle, WA, USA.
Source: Nature communications [Nat Commun] 2026 Apr 28; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72147-8