Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance.

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Title: Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance.
Authors: Wang J; Department of Oncologic Sciences, University of Utah, Salt Lake City, UT, USA., Wee Y; Department of Pathology, University of Utah, Salt Lake City, UT, USA.; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan., Jacob T; Providence Cancer Institute, Earle A. Chiles Research Institute, Portland, OR, USA., Rogers A; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Sorensen LK; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Brooks DM; Providence Cancer Institute, Earle A. Chiles Research Institute, Portland, OR, USA., Gupta P; Providence Cancer Institute, Earle A. Chiles Research Institute, Portland, OR, USA., Tay JKH; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Wilson EC; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Liu T; Department of Dermatology, University of Utah, Salt Lake City, UT, USA., Smith EA; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Gopal YNV; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McMahon M; Department of Oncologic Sciences, University of Utah, Salt Lake City, UT, USA.; Department of Dermatology, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Holmen SL; Department of Oncologic Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Judson-Torres RL; Department of Oncologic Sciences, University of Utah, Salt Lake City, UT, USA.; Department of Dermatology, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Wolff RK; Department of Pathology, University of Utah, Salt Lake City, UT, USA.; Providence Cancer Institute, Earle A. Chiles Research Institute, Portland, OR, USA., Grossmann AH; Department of Oncologic Sciences, University of Utah, Salt Lake City, UT, USA. allie.grossmann@providence.org.; Department of Pathology, University of Utah, Salt Lake City, UT, USA. allie.grossmann@providence.org.; Providence Cancer Institute, Earle A. Chiles Research Institute, Portland, OR, USA. allie.grossmann@providence.org.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. allie.grossmann@providence.org.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (23), pp. 2286-2298. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5594
DOI:10.1038/s41388-026-03805-w