Olfactomedin 4 orchestrates TGF-β/CEACAM6 axis, promoting cell-autonomous epithelial to mesenchymal transition during gallbladder epithelium carcinogenesis.

Saved in:
Bibliographic Details
Title: Olfactomedin 4 orchestrates TGF-β/CEACAM6 axis, promoting cell-autonomous epithelial to mesenchymal transition during gallbladder epithelium carcinogenesis.
Authors: Yang S; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Department of General Surgery, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Huang W; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Department of Pathology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Zeng Q; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Wang X; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Kunming Key Laboratory of Biotherapy, Kunming, China., Lin S; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Kunming Key Laboratory of Biotherapy, Kunming, China., Meng M; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Kunming Key Laboratory of Biotherapy, Kunming, China., Wang L; Department of Pathology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Wang H; Department of Gastroenterology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Wang R; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Department of General Surgery, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Li L; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Kunming Key Laboratory of Biotherapy, Kunming, China., Chen X; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Kunming Key Laboratory of Biotherapy, Kunming, China., Wei Z; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China.; Kunming Key Laboratory of Biotherapy, Kunming, China., Lin Z; Department of Thyroid Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Ye Q; Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China., Li R; Department of General Surgery, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Tan J; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China. tanjing@kmmu.edu.cn.; Department of General Surgery, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China. tanjing@kmmu.edu.cn.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China. tanjing@kmmu.edu.cn., Wang W; Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China. wangwenju@kmmu.edu.cn.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China. wangwenju@kmmu.edu.cn.; Kunming Key Laboratory of Biotherapy, Kunming, China. wangwenju@kmmu.edu.cn.
Source: Oncogene [Oncogene] 2026 Jul; Vol. 45 (24), pp. 2359-2374. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5594
DOI:10.1038/s41388-026-03808-7