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Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer.

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Title: Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer.
Authors: Han S; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea., Kim H; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea., Choi M; Department of Clinical Research Institute, Kyung Hee University Medical Center, Seoul, 02447, Republic of Korea., Kim BH; Department of Clinical Pharmacology and Therapeutics, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, 02447, Republic of Korea., Chae S; Department of Surgery, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, 02447, Republic of Korea. oparms@khu.ac.kr., Lee SG; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea. seokgeun@khu.ac.kr.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2026 Apr 29; Vol. 31 (5). Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42050204
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+M%22">Choi M</searchLink>; Department of Clinical Research Institute, Kyung Hee University Medical Center, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+BH%22">Kim BH</searchLink>; Department of Clinical Pharmacology and Therapeutics, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chae+S%22">Chae S</searchLink>; Department of Surgery, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, 02447, Republic of Korea. oparms@khu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Lee+SG%22">Lee SG</searchLink>; Department of Biomedical Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea. seokgeun@khu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%229712129%22">Apoptosis : an international journal on programmed cell death</searchLink> [Apoptosis] 2026 Apr 29; Vol. 31 (5). <i>Date of Electronic Publication: </i>2026 Apr 29.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9712129 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-675X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213608185%22">13608185 </searchLink><i>NLM ISO Abbreviation: </i>Apoptosis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10495-026-02340-z
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      – Code: eng
        Text: English
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      – TitleFull: Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer.
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            – D: 29
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              Text: 2026 Apr 29
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              Y: 2026
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              Value: 31
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              Value: 5
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            – TitleFull: Apoptosis : an international journal on programmed cell death
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