PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly.
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| Title: | PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly. |
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| Authors: | Shah RB; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Li Y; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Person A; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA., Frigon L; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Ðukić N; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Kini E; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen R; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada., Cohen MS; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA., Ahel I; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Haley JD; Department of Pathology Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA., Sidi S; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Source: | Science advances [Sci Adv] 2026 May; Vol. 12 (18), pp. eadz9284. Date of Electronic Publication: 2026 Apr 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42054439 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shah+RB%22">Shah RB</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Person+A%22">Person A</searchLink>; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Frigon+L%22">Frigon L</searchLink>; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ðukić+N%22">Ðukić N</searchLink>; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kini+E%22">Kini E</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pascal+JM%22">Pascal JM</searchLink>; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Cohen+MS%22">Cohen MS</searchLink>; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Ahel+I%22">Ahel I</searchLink>; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Haley+JD%22">Haley JD</searchLink>; Department of Pathology Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sidi+S%22">Sidi S</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 May; Vol. 12 (18), pp. eadz9284. <i>Date of Electronic Publication: </i>2026 Apr 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101653440 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2375-2548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223752548%22">23752548 </searchLink><i>NLM ISO Abbreviation: </i>Sci Adv <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42054439 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/sciadv.adz9284 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: eadz9284 Titles: – TitleFull: PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shah RB – PersonEntity: Name: NameFull: Li Y – PersonEntity: Name: NameFull: Person A – PersonEntity: Name: NameFull: Frigon L – PersonEntity: Name: NameFull: Ðukić N – PersonEntity: Name: NameFull: Kini E – PersonEntity: Name: NameFull: Chen R – PersonEntity: Name: NameFull: Pascal JM – PersonEntity: Name: NameFull: Cohen MS – PersonEntity: Name: NameFull: Ahel I – PersonEntity: Name: NameFull: Haley JD – PersonEntity: Name: NameFull: Sidi S IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2375-2548 Numbering: – Type: volume Value: 12 – Type: issue Value: 18 Titles: – TitleFull: Science advances Type: main |
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