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Extracellular vesicles co-delivery of Tangeretin to mitigate sepsis-induced acute lung injury by inhibiting macrophage ferroptosis via ALOX5/ACSL4 signaling pathway.

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Title: Extracellular vesicles co-delivery of Tangeretin to mitigate sepsis-induced acute lung injury by inhibiting macrophage ferroptosis via ALOX5/ACSL4 signaling pathway.
Authors: Guo Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Hu H; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Chen Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Wang C; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China., Zhang Y; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China., Wang D; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Zhuhai, Guangdong, China. Electronic address: david@gzucm.edu.cn., Liu Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Zhuhai, Guangdong, China; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong, China. Electronic address: iamliuyuntao@163.com.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Jul 15; Vol. 181, pp. 116735. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-1705
DOI:10.1016/j.intimp.2026.116735