Extracellular vesicles co-delivery of Tangeretin to mitigate sepsis-induced acute lung injury by inhibiting macrophage ferroptosis via ALOX5/ACSL4 signaling pathway.

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Title: Extracellular vesicles co-delivery of Tangeretin to mitigate sepsis-induced acute lung injury by inhibiting macrophage ferroptosis via ALOX5/ACSL4 signaling pathway.
Authors: Guo Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Hu H; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Chen Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Wang C; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China., Zhang Y; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China., Wang D; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Zhuhai, Guangdong, China. Electronic address: david@gzucm.edu.cn., Liu Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Zhuhai, Guangdong, China; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong, China. Electronic address: iamliuyuntao@163.com.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Jul 15; Vol. 181, pp. 116735. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
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  Data: Extracellular vesicles co-delivery of Tangeretin to mitigate sepsis-induced acute lung injury by inhibiting macrophage ferroptosis via ALOX5/ACSL4 signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Zhuhai, Guangdong, China. Electronic address: david@gzucm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, Guangdong, China; Chinese Medicine Guangdong Laboratory, Zhuhai, Guangdong, China; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou, Guangdong, China. Electronic address: iamliuyuntao@163.com.
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  Data: <searchLink fieldCode="JN" term="%22100965259%22">International immunopharmacology</searchLink> [Int Immunopharmacol] 2026 Jul 15; Vol. 181, pp. 116735. <i>Date of Electronic Publication: </i>2026 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>100965259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-1705 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215675769%22">15675769 </searchLink><i>NLM ISO Abbreviation: </i>Int Immunopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.intimp.2026.116735
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      – TitleFull: Extracellular vesicles co-delivery of Tangeretin to mitigate sepsis-induced acute lung injury by inhibiting macrophage ferroptosis via ALOX5/ACSL4 signaling pathway.
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              Text: 2026 Jul 15
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