Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex.

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Title: Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex.
Authors: Guenaga J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Ádori M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Bale S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Phulera S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Zygouras I; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Schleich FA; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Castro Dopico X; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Agrawal S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ota M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Wilson R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Cluff J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Dzvelaia T; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Mandolesi M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Walsh AA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Melo MB; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Verkoczy L; Applied Biomedical Science Institute, San Diego, CA, USA., Irvine DJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Corcoran M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Carnathan D; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. gunilla.karlsson.hedestam@ki.se.; Science for Life Laboratory, Stockholm, Sweden. gunilla.karlsson.hedestam@ki.se., Wyatt RT; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. wyatt@scripps.edu.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8119), pp. 777-785. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex.
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  Data: <searchLink fieldCode="AU" term="%22Guenaga+J%22">Guenaga J</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ádori+M%22">Ádori M</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bale+S%22">Bale S</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Phulera+S%22">Phulera S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zygouras+I%22">Zygouras I</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Schleich+FA%22">Schleich FA</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Castro+Dopico+X%22">Castro Dopico X</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Agrawal+S%22">Agrawal S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ota+M%22">Ota M</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cluff+J%22">Cluff J</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dzvelaia+T%22">Dzvelaia T</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mandolesi+M%22">Mandolesi M</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Lee+WH%22">Lee WH</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+AA%22">Walsh AA</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melo+MB%22">Melo MB</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Verkoczy+L%22">Verkoczy L</searchLink>; Applied Biomedical Science Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Irvine+DJ%22">Irvine DJ</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Corcoran+M%22">Corcoran M</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Wilson+IA%22">Wilson IA</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Carnathan+D%22">Carnathan D</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Silvestri+G%22">Silvestri G</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ozorowski+G%22">Ozorowski G</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Karlsson+Hedestam+GB%22">Karlsson Hedestam GB</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. gunilla.karlsson.hedestam@ki.se.; Science for Life Laboratory, Stockholm, Sweden. gunilla.karlsson.hedestam@ki.se.<br /><searchLink fieldCode="AU" term="%22Wyatt+RT%22">Wyatt RT</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. wyatt@scripps.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jun; Vol. 654 (8119), pp. 777-785. <i>Date of Electronic Publication: </i>2026 Apr 29.
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