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Reduced-intensity reinduction for children and young persons with relapsed acute lymphoblastic leukemia.

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Title: Reduced-intensity reinduction for children and young persons with relapsed acute lymphoblastic leukemia.
Authors: Hodder A; Great Ormond Street Hospital for Children, London, UK.; Wellcome Sanger Institute, Hinxton, UK., Mishra A; Great Ormond Street Hospital for Children, London, UK., Enshaei A; Leukemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Baird S; Royal Hospital for Sick Children, Edinburgh, UK., Bhuller K; Children's Hospital, Leicester Royal Infirmary, Leicester, UK., Castleton A; The Christie NHS Foundation Trust, Manchester, UK., Clesham K; University College London Hospitals NHS Trust, London, UK., Connor P; Children's Hospital for Wales, Cardiff, UK., Elbeshlawi I; Oxford University Hospital NHS Trust, Oxford, UK., Gattens M; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., George L; University Hospitals Birmingham, Birmingham, UK., Heaney N; The Royal Hospital for Children, Glasgow, UK., Ingham D; Leeds Children's Hospital, Leeds, UK., Jigoulina G; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Lindsay K; Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Madni M; Nottingham University Hospitals, Nottingham, UK., Malone A; Children's Health Ireland, Crumlin, Ireland., Mitchell B; Royal Belfast Hospital for Sick Children, Belfast, UK., Motwani J; Birmingham Children's Hospital, Birmingham, UK., Nicholson E; The Royal Marsden, London, UK., Patrick K; Sheffield Children's NHS Foundation Trust, Sheffield, UK., Ramanathan S; Newcastle Hospitals NHS Foundation Trust, Newcastle, UK., Taylor G; Aberdeen Royal Infirmary, Aberdeen, UK., Tewari S; The Royal Marsden, London, UK., Thakur I; Children's Hospital for Wales, Cardiff, UK., Samrin L; Great Ormond Street Hospital for Children, London, UK., McLelland V; Bristol Children's Hospital, Bristol, UK., Osborne C; Alder Hey Children's NHS Foundation Trust, Liverpool, UK., Hogan LE; Department of Pediatrics, Stony Brook Children's, Stony Brook, NY, USA., Cooper S; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA., Ji L; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Bhojwani D; Division of Hematology-Oncology, Children's Hospital Los Angeles, and Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Brown PA; BeOne Medicines, Cambridge, MA, USA., Hunger SP; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Loh ML; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, and the Department of Pediatrics, Seattle Children's Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA, USA., Bonney D; Royal Manchester Children's Hospital, Manchester, UK., Cummins M; Bristol Children's Hospital, Bristol, UK., van Delft F; Newcastle Hospitals NHS Foundation Trust, Newcastle, UK., Ghorashian S; Great Ormond Street Hospital for Children, London, UK.; UCL Cancer Institute, University College London, London, UK., Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Hough R; University College London Hospitals NHS Trust, London, UK., Moorman A; Leukemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Moppett J; Bristol Children's Hospital, Bristol, UK., Samarasinghe S; Great Ormond Street Hospital for Children, London, UK., Vora A; Great Ormond Street Hospital for Children, London, UK., O'Connor D; Great Ormond Street Hospital for Children, London, UK. david.oconnor@gosh.nhs.uk.
Source: Leukemia [Leukemia] 2026 Apr 30. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Letter
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hodder+A%22">Hodder A</searchLink>; Great Ormond Street Hospital for Children, London, UK.; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Mishra+A%22">Mishra A</searchLink>; Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Enshaei+A%22">Enshaei A</searchLink>; Leukemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Baird+S%22">Baird S</searchLink>; Royal Hospital for Sick Children, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Bhuller+K%22">Bhuller K</searchLink>; Children's Hospital, Leicester Royal Infirmary, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Castleton+A%22">Castleton A</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Clesham+K%22">Clesham K</searchLink>; University College London Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Connor+P%22">Connor P</searchLink>; Children's Hospital for Wales, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Elbeshlawi+I%22">Elbeshlawi I</searchLink>; Oxford University Hospital NHS Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gattens+M%22">Gattens M</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22George+L%22">George L</searchLink>; University Hospitals Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Heaney+N%22">Heaney N</searchLink>; The Royal Hospital for Children, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ingham+D%22">Ingham D</searchLink>; Leeds Children's Hospital, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Jigoulina+G%22">Jigoulina G</searchLink>; University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Lindsay+K%22">Lindsay K</searchLink>; Alder Hey Children's NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Madni+M%22">Madni M</searchLink>; Nottingham University Hospitals, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Malone+A%22">Malone A</searchLink>; Children's Health Ireland, Crumlin, Ireland.<br /><searchLink fieldCode="AU" term="%22Mitchell+B%22">Mitchell B</searchLink>; Royal Belfast Hospital for Sick Children, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Motwani+J%22">Motwani J</searchLink>; Birmingham Children's Hospital, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Nicholson+E%22">Nicholson E</searchLink>; The Royal Marsden, London, UK.<br /><searchLink fieldCode="AU" term="%22Patrick+K%22">Patrick K</searchLink>; Sheffield Children's NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Ramanathan+S%22">Ramanathan S</searchLink>; Newcastle Hospitals NHS Foundation Trust, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+G%22">Taylor G</searchLink>; Aberdeen Royal Infirmary, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Tewari+S%22">Tewari S</searchLink>; The Royal Marsden, London, UK.<br /><searchLink fieldCode="AU" term="%22Thakur+I%22">Thakur I</searchLink>; Children's Hospital for Wales, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Samrin+L%22">Samrin L</searchLink>; Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22McLelland+V%22">McLelland V</searchLink>; Bristol Children's Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Osborne+C%22">Osborne C</searchLink>; Alder Hey Children's NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hogan+LE%22">Hogan LE</searchLink>; Department of Pediatrics, Stony Brook Children's, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cooper+S%22">Cooper S</searchLink>; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ji+L%22">Ji L</searchLink>; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhojwani+D%22">Bhojwani D</searchLink>; Division of Hematology-Oncology, Children's Hospital Los Angeles, and Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+PA%22">Brown PA</searchLink>; BeOne Medicines, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hunger+SP%22">Hunger SP</searchLink>; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Loh+ML%22">Loh ML</searchLink>; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, and the Department of Pediatrics, Seattle Children's Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bonney+D%22">Bonney D</searchLink>; Royal Manchester Children's Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Cummins+M%22">Cummins M</searchLink>; Bristol Children's Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22van+Delft+F%22">van Delft F</searchLink>; Newcastle Hospitals NHS Foundation Trust, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Ghorashian+S%22">Ghorashian S</searchLink>; Great Ormond Street Hospital for Children, London, UK.; UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Halsey+C%22">Halsey C</searchLink>; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Hough+R%22">Hough R</searchLink>; University College London Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Moorman+A%22">Moorman A</searchLink>; Leukemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Moppett+J%22">Moppett J</searchLink>; Bristol Children's Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Samarasinghe+S%22">Samarasinghe S</searchLink>; Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Vora+A%22">Vora A</searchLink>; Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Connor+D%22">O'Connor D</searchLink>; Great Ormond Street Hospital for Children, London, UK. david.oconnor@gosh.nhs.uk.
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