Early secondary outcome analysis in multi-phase randomised-controlled trials, a pragmatic approach: the Healthy Life Trajectories Initiative (HeLTI).

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Title: Early secondary outcome analysis in multi-phase randomised-controlled trials, a pragmatic approach: the Healthy Life Trajectories Initiative (HeLTI).
Authors: Kumaran K; University of Southampton, Southampton, UK.; CSI Holdsworth Memorial Hospital, Mysuru, India., Baillargeon JP; University of Sherbrooke, Sherbrooke, QC, Canada., Birken CS; SickKids Research Institute, Toronto, ON, Canada.; University of Toronto, Toronto, ON, Canada., Dennis CL; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Fan J; The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China., Fraser WD; University of Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Huang H; Zhejiang University School of Medicine, Hangzhou, China., Hung RJ; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Suryanarayana KG; Vivekananda Memorial Hospital, Swami Vivekananda Youth Movement, Mysuru, India., Lye SJ; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Norris SA; University of Southampton, Southampton, UK.; SAMRC-Wits Developmental Pathways for Health Research, University of the Witwatersrand, Johannesburg, South Africa., Matthews SG; University of Toronto, Toronto, ON, Canada. stephen.matthews@utoronto.ca.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada. stephen.matthews@utoronto.ca.
Source: Trials [Trials] 2026 Apr 30; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-6215
DOI:10.1186/s13063-026-09737-w