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Early secondary outcome analysis in multi-phase randomised-controlled trials, a pragmatic approach: the Healthy Life Trajectories Initiative (HeLTI).

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Title: Early secondary outcome analysis in multi-phase randomised-controlled trials, a pragmatic approach: the Healthy Life Trajectories Initiative (HeLTI).
Authors: Kumaran K; University of Southampton, Southampton, UK.; CSI Holdsworth Memorial Hospital, Mysuru, India., Baillargeon JP; University of Sherbrooke, Sherbrooke, QC, Canada., Birken CS; SickKids Research Institute, Toronto, ON, Canada.; University of Toronto, Toronto, ON, Canada., Dennis CL; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Fan J; The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China., Fraser WD; University of Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Huang H; Zhejiang University School of Medicine, Hangzhou, China., Hung RJ; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Suryanarayana KG; Vivekananda Memorial Hospital, Swami Vivekananda Youth Movement, Mysuru, India., Lye SJ; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Norris SA; University of Southampton, Southampton, UK.; SAMRC-Wits Developmental Pathways for Health Research, University of the Witwatersrand, Johannesburg, South Africa., Matthews SG; University of Toronto, Toronto, ON, Canada. stephen.matthews@utoronto.ca.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada. stephen.matthews@utoronto.ca.
Source: Trials [Trials] 2026 Apr 30; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kumaran+K%22">Kumaran K</searchLink>; University of Southampton, Southampton, UK.; CSI Holdsworth Memorial Hospital, Mysuru, India.<br /><searchLink fieldCode="AU" term="%22Baillargeon+JP%22">Baillargeon JP</searchLink>; University of Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Birken+CS%22">Birken CS</searchLink>; SickKids Research Institute, Toronto, ON, Canada.; University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dennis+CL%22">Dennis CL</searchLink>; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Fraser+WD%22">Fraser WD</searchLink>; University of Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Hung+RJ%22">Hung RJ</searchLink>; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Suryanarayana+KG%22">Suryanarayana KG</searchLink>; Vivekananda Memorial Hospital, Swami Vivekananda Youth Movement, Mysuru, India.<br /><searchLink fieldCode="AU" term="%22Lye+SJ%22">Lye SJ</searchLink>; University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Norris+SA%22">Norris SA</searchLink>; University of Southampton, Southampton, UK.; SAMRC-Wits Developmental Pathways for Health Research, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Matthews+SG%22">Matthews SG</searchLink>; University of Toronto, Toronto, ON, Canada. stephen.matthews@utoronto.ca.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada. stephen.matthews@utoronto.ca.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Apr 30; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Apr 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13063-026-09737-w
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              Text: 2026 Apr 30
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