Deciphering the NEK7-NLRP3 inflammasome assembly: from conformational activation to allosteric drug discovery.
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| Title: | Deciphering the NEK7-NLRP3 inflammasome assembly: from conformational activation to allosteric drug discovery. |
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| Authors: | Gu CL; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China., Liu DD; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China., Chen H; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China., Wei XH; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China., Shang HC; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Apr 14; Vol. 17, pp. 1773422. Date of Electronic Publication: 2026 Apr 14 (Print Publication: 2026). |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1773422 |
