Licochalcone E Ameliorates Hepatic Steatosis in Obese Mice by Activating the Sirt1/AMPK Pathway and Reducing Hepatic Lipid Accumulation.

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Title: Licochalcone E Ameliorates Hepatic Steatosis in Obese Mice by Activating the Sirt1/AMPK Pathway and Reducing Hepatic Lipid Accumulation.
Authors: Huang WC; Graduate Institute of Health Industry Technology, Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan.; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan City 33378, Taiwan.; Department of Pediatrics, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei 23656, Taiwan., Wu SJ; Department of Nutrition and Health Sciences, Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan.; Aesthetic Medical Center, Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan 33342, Taiwan., Liu XM; Graduate Institute of Health Industry Technology, Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan., Cheng SC; Graduate Institute of Health Industry Technology, Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan.; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan City 33378, Taiwan., Lin PT; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan.; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan City 33342, Taiwan., Kuo CL; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan City 33378, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan., Liou CJ; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan City 33378, Taiwan.; Department of Nursing, Division of Basic Medical Sciences, Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan.
Source: Biomolecules & therapeutics [Biomol Ther (Seoul)] 2026 May 01; Vol. 34 (3), pp. 676-688. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Korean Society of Applied Pharmacology Country of Publication: Korea (South) NLM ID: 101472832 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1976-9148 (Print) Linking ISSN: 19769148 NLM ISO Abbreviation: Biomol Ther (Seoul) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1976-9148
DOI:10.4062/biomolther.2025.162