Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.

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Title: Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.
Authors: Guldan M; School of Medicine, Koç University, Istanbul, Turkey., Ozbek L; School of Medicine, Koç University, Istanbul, Turkey., Fidan DG; School of Medicine, Koç University, Istanbul, Turkey., Narin AE; School of Medicine, Koç University, Istanbul, Turkey., Hansen D; Department of Nephrology, Copenhagen University Hospital - Herlev, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Diaz-Tocados JM; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.; Cooperative Research Network Oriented Towards Health Outcomes (RICORS), Carlos III Health Institute (ISCIII), 28029, Madrid, Spain., Haarhaus M; Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.; Diaverum Sweden, Malmö, Sweden., de Borst MH; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Alfieri C; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan, 20122, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, 20122, Milan, Italy., Ferraro PM; Section of Nephrology, Department of Medicine, Università degli Studi di Verona and Nephrology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Bellasi A; Service of Nephrology, Ospedale Regionale di Lugano, Ospedale Civico, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland., Kanbay M; Division of Nephrology, Department of Internal Medicine, School of Medicine, Koç University, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey. mkanbay@ku.edu.tr.
Source: Calcified tissue international [Calcif Tissue Int] 2026 Apr 30; Vol. 117 (1). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0827
DOI:10.1007/s00223-026-01537-3