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Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.

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Title: Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.
Authors: Guldan M; School of Medicine, Koç University, Istanbul, Turkey., Ozbek L; School of Medicine, Koç University, Istanbul, Turkey., Fidan DG; School of Medicine, Koç University, Istanbul, Turkey., Narin AE; School of Medicine, Koç University, Istanbul, Turkey., Hansen D; Department of Nephrology, Copenhagen University Hospital - Herlev, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Diaz-Tocados JM; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.; Cooperative Research Network Oriented Towards Health Outcomes (RICORS), Carlos III Health Institute (ISCIII), 28029, Madrid, Spain., Haarhaus M; Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.; Diaverum Sweden, Malmö, Sweden., de Borst MH; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Alfieri C; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan, 20122, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, 20122, Milan, Italy., Ferraro PM; Section of Nephrology, Department of Medicine, Università degli Studi di Verona and Nephrology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Bellasi A; Service of Nephrology, Ospedale Regionale di Lugano, Ospedale Civico, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland., Kanbay M; Division of Nephrology, Department of Internal Medicine, School of Medicine, Koç University, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey. mkanbay@ku.edu.tr.
Source: Calcified tissue international [Calcif Tissue Int] 2026 Apr 30; Vol. 117 (1). Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group.
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  Data: <searchLink fieldCode="AU" term="%22Guldan+M%22">Guldan M</searchLink>; School of Medicine, Koç University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Ozbek+L%22">Ozbek L</searchLink>; School of Medicine, Koç University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Fidan+DG%22">Fidan DG</searchLink>; School of Medicine, Koç University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Narin+AE%22">Narin AE</searchLink>; School of Medicine, Koç University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Hansen+D%22">Hansen D</searchLink>; Department of Nephrology, Copenhagen University Hospital - Herlev, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Diaz-Tocados+JM%22">Diaz-Tocados JM</searchLink>; Vascular and Renal Translational Research Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.; Cooperative Research Network Oriented Towards Health Outcomes (RICORS), Carlos III Health Institute (ISCIII), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Haarhaus+M%22">Haarhaus M</searchLink>; Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.; Diaverum Sweden, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22de+Borst+MH%22">de Borst MH</searchLink>; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Alfieri+C%22">Alfieri C</searchLink>; Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan, 20122, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, 20122, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferraro+PM%22">Ferraro PM</searchLink>; Section of Nephrology, Department of Medicine, Università degli Studi di Verona and Nephrology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Bellasi+A%22">Bellasi A</searchLink>; Service of Nephrology, Ospedale Regionale di Lugano, Ospedale Civico, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kanbay+M%22">Kanbay M</searchLink>; Division of Nephrology, Department of Internal Medicine, School of Medicine, Koç University, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey. mkanbay@ku.edu.tr.
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  Data: <searchLink fieldCode="JN" term="%227905481%22">Calcified tissue international</searchLink> [Calcif Tissue Int] 2026 Apr 30; Vol. 117 (1). <i>Date of Electronic Publication: </i>2026 Apr 30.
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