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Toward life with a 19-amino acid alphabet through generative artificial intelligence design.

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Title: Toward life with a 19-amino acid alphabet through generative artificial intelligence design.
Authors: Liu L; Department of Systems Biology, Columbia University, New York, NY, USA., Rochereau C; Department of Systems Biology, Columbia University, New York, NY, USA.; Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, NY, USA., Kozlov S; Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Urtecho G; Department of Systems Biology, Columbia University, New York, NY, USA., Liu X; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biostatistics, Harvard University, Cambridge, MA, USA., Zhao J; Department of Systems Biology, Columbia University, New York, NY, USA., Wang J; Department of Systems Biology, Columbia University, New York, NY, USA., Huang Y; Department of Systems Biology, Columbia University, New York, NY, USA., Qu Y; Department of Systems Biology, Columbia University, New York, NY, USA., Zhang Z; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Blazejewski T; Department of Systems Biology, Columbia University, New York, NY, USA.; Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, NY, USA., Swartz A; Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA., Ovchinnikov S; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; John Harvard Distinguished Science Fellowship, Harvard University, Cambridge, MA, USA., Wang HH; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Source: Science (New York, N.Y.) [Science] 2026 Apr 30; Vol. 392 (6797), pp. eaeb5171. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rochereau+C%22">Rochereau C</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.; Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kozlov+S%22">Kozlov S</searchLink>; Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Urtecho+G%22">Urtecho G</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biostatistics, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Qu+Y%22">Qu Y</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Blazejewski+T%22">Blazejewski T</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.; Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Swartz+A%22">Swartz A</searchLink>; Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ovchinnikov+S%22">Ovchinnikov S</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; John Harvard Distinguished Science Fellowship, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+HH%22">Wang HH</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
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