Pharmacokinetic Drug-Drug Interaction of Leritrelvir in Healthy Chinese Volunteers: A Single-Arm, Open-Label, Dual-Cohort Study.

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Title: Pharmacokinetic Drug-Drug Interaction of Leritrelvir in Healthy Chinese Volunteers: A Single-Arm, Open-Label, Dual-Cohort Study.
Authors: Peng J; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.; Drug Clinical Trial Institution, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, Guangzhou, China., Chen J; Drug Clinical Trial Institution, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Du XX; Drug Clinical Trial Institution, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Li HJ; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.; Guangdong Raynovent Biotechnology Co., Ltd., Guangzhou, China., Qin RZ; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Chen SH; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Liu X; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Cheng Q; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Li XM; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Huang DX; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Duan L; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Li MY; Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Wu WZ; Department of Urology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Ye LK; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China., Li YY; Guangdong Raynovent Biotechnology Co., Ltd., Guangzhou, China., Xie ZH; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China. xzh0302@126.com., Han K; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China. cjy-ke@163.com.; Drug Clinical Trial Institution, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. cjy-ke@163.com.
Source: Clinical drug investigation [Clin Drug Investig] 2026 Jun; Vol. 46 (6), pp. 609-618. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9504817 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1918 (Electronic) Linking ISSN: 11732563 NLM ISO Abbreviation: Clin Drug Investig Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacokinetic Drug-Drug Interaction of Leritrelvir in Healthy Chinese Volunteers: A Single-Arm, Open-Label, Dual-Cohort Study.
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  Data: <searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.; Drug Clinical Trial Institution, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Drug Clinical Trial Institution, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Du+XX%22">Du XX</searchLink>; Drug Clinical Trial Institution, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+HJ%22">Li HJ</searchLink>; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.; Guangdong Raynovent Biotechnology Co., Ltd., Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Qin+RZ%22">Qin RZ</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+SH%22">Chen SH</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Cheng+Q%22">Cheng Q</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+XM%22">Li XM</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Huang+DX%22">Huang DX</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Duan+L%22">Duan L</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+MY%22">Li MY</searchLink>; Department of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+WZ%22">Wu WZ</searchLink>; Department of Urology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ye+LK%22">Ye LK</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+YY%22">Li YY</searchLink>; Guangdong Raynovent Biotechnology Co., Ltd., Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+ZH%22">Xie ZH</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China. xzh0302@126.com.<br /><searchLink fieldCode="AU" term="%22Han+K%22">Han K</searchLink>; Phase I Clinical Trial Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China. cjy-ke@163.com.; Drug Clinical Trial Institution, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. cjy-ke@163.com.
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  Data: <searchLink fieldCode="JN" term="%229504817%22">Clinical drug investigation</searchLink> [Clin Drug Investig] 2026 Jun; Vol. 46 (6), pp. 609-618. <i>Date of Electronic Publication: </i>2026 May 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9504817 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1918 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211732563%22">11732563 </searchLink><i>NLM ISO Abbreviation: </i>Clin Drug Investig <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s40261-026-01556-w
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        Text: English
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        StartPage: 609
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      – TitleFull: Pharmacokinetic Drug-Drug Interaction of Leritrelvir in Healthy Chinese Volunteers: A Single-Arm, Open-Label, Dual-Cohort Study.
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              Text: 2026 Jun
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