The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant).

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Title: The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant).
Authors: Niessen J; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden., Koziolek M; Synthetic Molecules CMC R&D, AbbVie Deutschland GmbH & Co. KG, Knollstrasse, Ludwigshafen am Rhein 67061, Germany., Indulkar A; AbbVie Small Molecule CMC Development, 1N Waukegan Road, North Chicago 07065, Illinois, United States., Borchardt T; AbbVie Product Development Science and Technology, 1N Waukegan Road, North Chicago 07065, Illinois, United States., Sjöblom M; Department of Medical Cell Biology, Uppsala University, Uppsala 751 05, Sweden., Hedeland M; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala 751 05, Sweden., Lennernäs H; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden., Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 751 05, Sweden.
Source: Molecular pharmaceutics [Mol Pharm] 2026 Jun 01; Vol. 23 (6), pp. 3445-3457. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1543-8392
DOI:10.1021/acs.molpharmaceut.6c00207