Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader.

Saved in:
Bibliographic Details
Title: Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader.
Authors: Azeez KRA; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Saraswati H; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Mosler T; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Hanke T; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Ho-Xuan H; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Neder N; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Sivashanmugam SA; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Heinz M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany., Schwalm MP; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Giuliani G; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Rathore R; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Kazi R; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Kumar R; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Mitrovic M; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Prieto-Garcia C; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Bailey HJ; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Mathea S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany.; Institute for Biophysics, Goethe University Frankfurt, Frankfurt am Main 60438, Germany., Đikić I; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Müller S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Stolz A; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Krause DS; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Cancer Consortium (DKTK) Mainz/Frankfurt, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, 55131 Mainz, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) Mainz/Frankfurt, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Source: ACS chemical biology [ACS Chem Biol] 2026 May 15; Vol. 21 (5), pp. 1158-1176. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-8937
DOI:10.1021/acschembio.6c00137