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Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader.

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Title: Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader.
Authors: Azeez KRA; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Saraswati H; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Mosler T; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Hanke T; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Ho-Xuan H; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Neder N; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Sivashanmugam SA; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Heinz M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany., Schwalm MP; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Giuliani G; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Rathore R; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Kazi R; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Kumar R; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany., Mitrovic M; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Prieto-Garcia C; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany., Bailey HJ; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Mathea S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany.; Institute for Biophysics, Goethe University Frankfurt, Frankfurt am Main 60438, Germany., Đikić I; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Müller S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Stolz A; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany., Krause DS; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Cancer Consortium (DKTK) Mainz/Frankfurt, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, 55131 Mainz, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) Mainz/Frankfurt, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Source: ACS chemical biology [ACS Chem Biol] 2026 May 15; Vol. 21 (5), pp. 1158-1176. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader.
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  Data: <searchLink fieldCode="AU" term="%22Azeez+KRA%22">Azeez KRA</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Saraswati+H%22">Saraswati H</searchLink>; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Mosler+T%22">Mosler T</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.<br /><searchLink fieldCode="AU" term="%22Hanke+T%22">Hanke T</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Ho-Xuan+H%22">Ho-Xuan H</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Neder+N%22">Neder N</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Sivashanmugam+SA%22">Sivashanmugam SA</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Heinz+M%22">Heinz M</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany.<br /><searchLink fieldCode="AU" term="%22Schwalm+MP%22">Schwalm MP</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Giuliani+G%22">Giuliani G</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Rathore+R%22">Rathore R</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.<br /><searchLink fieldCode="AU" term="%22Kazi+R%22">Kazi R</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.<br /><searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Mitrovic+M%22">Mitrovic M</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Prieto-Garcia+C%22">Prieto-Garcia C</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.<br /><searchLink fieldCode="AU" term="%22Bailey+HJ%22">Bailey HJ</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Mathea+S%22">Mathea S</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Hummer+G%22">Hummer G</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main 60438, Germany.; Institute for Biophysics, Goethe University Frankfurt, Frankfurt am Main 60438, Germany.<br /><searchLink fieldCode="AU" term="%22Đikić+I%22">Đikić I</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+S%22">Müller S</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Stolz+A%22">Stolz A</searchLink>; Institute of Biochemistry II, School of Medicine, Goethe University Frankfurt, Frankfurt am Main 60590, Germany.; Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Krause+DS%22">Krause DS</searchLink>; Institute of Transfusion Medicine-Transfusion Centre, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; German Cancer Consortium (DKTK) Mainz/Frankfurt, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, 55131 Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) Mainz/Frankfurt, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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