CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.

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Title: CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.
Authors: Mast N; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA., Bederman I; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., El-Darzi N; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA., Pikuleva IA; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: iap8@case.edu.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119470. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2026.119470