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CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.

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Title: CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.
Authors: Mast N; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA., Bederman I; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., El-Darzi N; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA., Pikuleva IA; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: iap8@case.edu.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119470. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mast+N%22">Mast N</searchLink>; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Bederman+I%22">Bederman I</searchLink>; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22El-Darzi+N%22">El-Darzi N</searchLink>; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Pikuleva+IA%22">Pikuleva IA</searchLink>; Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: iap8@case.edu.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119470. <i>Date of Electronic Publication: </i>2026 Apr 30.
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        Value: 10.1016/j.biopha.2026.119470
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      – TitleFull: CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.
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              Text: 2026 Jun
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