An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut.

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Title: An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut.
Authors: Spiga L; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Fansler RT; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Wu Y; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Grote A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Langford-Butler M; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Miller AK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Neal M; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Hale OF; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA; Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA., Singla D; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Calcutt MW; Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA., Rose AE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Bresson MM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Schrimpe-Rutledge AC; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Berdy B; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Codreanu SG; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Washington MK; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA., Bratton BP; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Sherrod SD; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN, USA., McLean JA; Center for Innovative Technology and Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Zengler K; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA; Program in Materials Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Sears CL; Department of Microbiology and Molecular Immunology, Bloomberg School of Public Health, Baltimore, MD, USA; Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Behringer MG; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA; Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA., Gnirke A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tao L; Division of Laboratory Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Livny J; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Olivares-Villagómez D; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., Earl AM; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: aearl@broadinstitute.org., Zhu W; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: wenhan.zhu@vumc.org.
Source: Cell [Cell] 2026 Jun 25; Vol. 189 (13), pp. 3968-3990.e38. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2026.04.012