Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial.

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Title: Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial.
Authors: Tarpgaard LS; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address: line.tarpgaard@rsyd.dk., Poulsen LØ; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Gögenur I; Center for Surgical Science, Zealand University Hospital, Køge, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Justesen TF; Center for Surgical Science, Zealand University Hospital, Køge, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Rafaelsen SR; Department of Radiology, Vejle Hospital, Vejle, Denmark., Øgaard N; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Demuth C; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Andersen CL; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Ventzel L; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Oncology, Vejle Hospital, Vejle, Denmark., Larsen PØ; Department of Surgery, Vejle Hospital, Vejle, Denmark., Ramlov A; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Ljungmann K; Department of Surgery, Aarhus University Hospital, Aarhus, Denmark., Lauritzen MB; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark., Diness LV; Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Lykke J; Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark., de Lima VAB; Department of Oncology, Rigshospitalet, Copenhagen, Denmark., Kjær S; Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark., Salomon S; Department of Surgery, Odense University Hospital, Odense, Denmark., Andersen PV; Department of Surgery, Odense University Hospital, Odense, Denmark., Pfeiffer P; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 570-578. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2468-1253
DOI:10.1016/S2468-1253(26)00047-6