Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial.
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| Title: | Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial. |
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| Authors: | Tarpgaard LS; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address: line.tarpgaard@rsyd.dk., Poulsen LØ; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Gögenur I; Center for Surgical Science, Zealand University Hospital, Køge, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Justesen TF; Center for Surgical Science, Zealand University Hospital, Køge, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Rafaelsen SR; Department of Radiology, Vejle Hospital, Vejle, Denmark., Øgaard N; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Demuth C; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Andersen CL; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Ventzel L; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Oncology, Vejle Hospital, Vejle, Denmark., Larsen PØ; Department of Surgery, Vejle Hospital, Vejle, Denmark., Ramlov A; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Ljungmann K; Department of Surgery, Aarhus University Hospital, Aarhus, Denmark., Lauritzen MB; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark., Diness LV; Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Lykke J; Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark., de Lima VAB; Department of Oncology, Rigshospitalet, Copenhagen, Denmark., Kjær S; Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark., Salomon S; Department of Surgery, Odense University Hospital, Odense, Denmark., Andersen PV; Department of Surgery, Odense University Hospital, Odense, Denmark., Pfeiffer P; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. |
| Source: | The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 570-578. Date of Electronic Publication: 2026 Apr 28. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42066786 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tarpgaard+LS%22">Tarpgaard LS</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address: line.tarpgaard@rsyd.dk.<br /><searchLink fieldCode="AU" term="%22Poulsen+LØ%22">Poulsen LØ</searchLink>; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Gögenur+I%22">Gögenur I</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Justesen+TF%22">Justesen TF</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rafaelsen+SR%22">Rafaelsen SR</searchLink>; Department of Radiology, Vejle Hospital, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Øgaard+N%22">Øgaard N</searchLink>; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Demuth+C%22">Demuth C</searchLink>; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+CL%22">Andersen CL</searchLink>; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ventzel+L%22">Ventzel L</searchLink>; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Oncology, Vejle Hospital, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+PØ%22">Larsen PØ</searchLink>; Department of Surgery, Vejle Hospital, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Ramlov+A%22">Ramlov A</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ljungmann+K%22">Ljungmann K</searchLink>; Department of Surgery, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Lauritzen+MB%22">Lauritzen MB</searchLink>; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Diness+LV%22">Diness LV</searchLink>; Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Lykke+J%22">Lykke J</searchLink>; Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22de+Lima+VAB%22">de Lima VAB</searchLink>; Department of Oncology, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kjær+S%22">Kjær S</searchLink>; Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Salomon+S%22">Salomon S</searchLink>; Department of Surgery, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+PV%22">Andersen PV</searchLink>; Department of Surgery, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+P%22">Pfeiffer P</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101690683%22">The lancet. Gastroenterology & hepatology</searchLink> [Lancet Gastroenterol Hepatol] 2026 Jul; Vol. 11 (7), pp. 570-578. <i>Date of Electronic Publication: </i>2026 Apr 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101690683 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2468-1253 (Electronic) <i>NLM ISO Abbreviation: </i>Lancet Gastroenterol Hepatol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42066786 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S2468-1253(26)00047-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 570 Titles: – TitleFull: Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tarpgaard LS – PersonEntity: Name: NameFull: Poulsen LØ – PersonEntity: Name: NameFull: Gögenur I – PersonEntity: Name: NameFull: Justesen TF – PersonEntity: Name: NameFull: Rafaelsen SR – PersonEntity: Name: NameFull: Øgaard N – PersonEntity: Name: NameFull: Demuth C – PersonEntity: Name: NameFull: Andersen CL – PersonEntity: Name: NameFull: Ventzel L – PersonEntity: Name: NameFull: Larsen PØ – PersonEntity: Name: NameFull: Ramlov A – PersonEntity: Name: NameFull: Ljungmann K – PersonEntity: Name: NameFull: Lauritzen MB – PersonEntity: Name: NameFull: Diness LV – PersonEntity: Name: NameFull: Lykke J – PersonEntity: Name: NameFull: de Lima VAB – PersonEntity: Name: NameFull: Kjær S – PersonEntity: Name: NameFull: Salomon S – PersonEntity: Name: NameFull: Andersen PV – PersonEntity: Name: NameFull: Pfeiffer P IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2468-1253 Numbering: – Type: volume Value: 11 – Type: issue Value: 7 Titles: – TitleFull: The lancet. Gastroenterology & hepatology Type: main |
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