Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer.
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| Title: | Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer. |
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| Authors: | Jamroze A; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Anmbreen.Jamroze@Roswellpark.org., Liu X; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Hou S; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Jess Li W; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY, USA.; Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Yu H; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Tracz A; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Jacobi J; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Li Q; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China., Nastiuk K; Departments of Cancer Genetics and Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Chen X; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Huang J; Department of Pathology, Duke University School of Medicine, Durham, NC, USA., Lin K; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, Houston, TX, USA., Liu M; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USA., Cai C; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USA., Lu Y; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, Houston, TX, USA., Puzanov I; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Kirk JS; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Chatta G; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Tang DG; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Dean.Tang@Roswellpark.org.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY, USA. Dean.Tang@Roswellpark.org. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 01; Vol. 11 (1). Date of Electronic Publication: 2026 May 01. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42067541 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jamroze+A%22">Jamroze A</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Anmbreen.Jamroze@Roswellpark.org.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hou+S%22">Hou S</searchLink>; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jess+Li+W%22">Jess Li W</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY, USA.; Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tracz+A%22">Tracz A</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jacobi+J%22">Jacobi J</searchLink>; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Nastiuk+K%22">Nastiuk K</searchLink>; Departments of Cancer Genetics and Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+C%22">Cai C</searchLink>; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Puzanov+I%22">Puzanov I</searchLink>; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kirk+JS%22">Kirk JS</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chatta+G%22">Chatta G</searchLink>; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tang+DG%22">Tang DG</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Dean.Tang@Roswellpark.org.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY, USA. Dean.Tang@Roswellpark.org. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 May 01; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 May 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42067541 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41392-026-02700-w Languages: – Code: eng Text: English Titles: – TitleFull: Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jamroze A – PersonEntity: Name: NameFull: Liu X – PersonEntity: Name: NameFull: Hou S – PersonEntity: Name: NameFull: Jess Li W – PersonEntity: Name: NameFull: Yu H – PersonEntity: Name: NameFull: Tracz A – PersonEntity: Name: NameFull: Jacobi J – PersonEntity: Name: NameFull: Li Q – PersonEntity: Name: NameFull: Nastiuk K – PersonEntity: Name: NameFull: Chen X – PersonEntity: Name: NameFull: Huang J – PersonEntity: Name: NameFull: Lin K – PersonEntity: Name: NameFull: Liu M – PersonEntity: Name: NameFull: Cai C – PersonEntity: Name: NameFull: Lu Y – PersonEntity: Name: NameFull: Puzanov I – PersonEntity: Name: NameFull: Kirk JS – PersonEntity: Name: NameFull: Chatta G – PersonEntity: Name: NameFull: Tang DG IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2059-3635 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Signal transduction and targeted therapy Type: main |
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