Interferon-alpha selectively signals mitochondrial pore opening to allow mitochondrial RNA release in systemic lupus erythematosus: pathophysiological implications.

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Title: Interferon-alpha selectively signals mitochondrial pore opening to allow mitochondrial RNA release in systemic lupus erythematosus: pathophysiological implications.
Authors: Huang CY; Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, ROC.; Graduate Institute of Life Sciences, College of Biomedical Sciences, National Defense Medical University, Taipei, Taiwan, ROC., Wu DW; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, ROC., Hung LF; Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, ROC., Wu CH; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, ROC., Luo SF; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, ROC., Ka SM; Graduate Institute of Aerospace and Undersea Medicine, Department of Medicine, National Defense Medical University, Taipei, Taiwan, ROC., Chen A; Department of Pathology, Hualien TZU CHI Medical Center, Hualien, Taiwan, ROC., Ho LJ; Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, ROC. lingjunho@nhri.org.tw.; Graduate Institute of Life Sciences, College of Biomedical Sciences, National Defense Medical University, Taipei, Taiwan, ROC. lingjunho@nhri.org.tw., Lai JH; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, ROC. laiandho@gmail.com.; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, ROC. laiandho@gmail.com.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 May 01; Vol. 24 (1). Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1478-811X
DOI:10.1186/s12964-026-02910-3