Chlorhexidine gluconate vs povidone-iodine for surgical site infection prevention: a systematic review and meta-analysis stratified by surgery type, wound classification, antiseptic formulation, and country income, with meta-regression.

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Title: Chlorhexidine gluconate vs povidone-iodine for surgical site infection prevention: a systematic review and meta-analysis stratified by surgery type, wound classification, antiseptic formulation, and country income, with meta-regression.
Authors: Benhammou M; Faculty of Medicine, University of Oran 1, Ahmed Ben Bella, Oran, Algeria., Elraggal D; Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt., Saleh S; The Hashemite University, Zarqa, Jordan., Nobuhara CK; Department of Surgery, Stanford University, Stanford, CA, USA., van Ramshorst GH; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium; Department of Human Structure and Repair, Ghent University, Ghent, Belgium., Mimoz O; CHU de Poitiers, Service des Urgences Adultes-SAS 86-Centre 15, Poitiers, France; INSERM, U1070, Pharmacologie des Agents Anti-Infectieux, Poitiers, France; Alliance for Vascular Access Teaching and Research, Griffith University, Nathan, Queensland, Australia., Nounou MV; University of Nouakchott Al Aasrya, Faculty of Medicine, Nouakchott, Mauritania., Shawesh Q; Department of Internal Medicine, HCA Mountain View Hospital, Las Vegas, NV, USA., Tuuli MG; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, RI, USA., Wexner SD; Division of Colorectal Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Catena F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of General and Emergency Surgery Bufalini Hospital AUSL Romagna Cesena ITALY, Italy., Forrester JD; Department of Surgery, Stanford University, Stanford, CA, USA., Elhadi M; College of Medicine, Korea University, Seoul, South Korea. Electronic address: muhammed-elhadi@korea.ac.kr.
Source: The Journal of hospital infection [J Hosp Infect] 2026 Jul; Vol. 173, pp. 140-153. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Comparative Study; Review
Journal Info: Publisher: W.B. Saunders For The Hospital Infection Society Country of Publication: England NLM ID: 8007166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2939 (Electronic) Linking ISSN: 01956701 NLM ISO Abbreviation: J Hosp Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-2939
DOI:10.1016/j.jhin.2026.04.015