Chlorhexidine gluconate vs povidone-iodine for surgical site infection prevention: a systematic review and meta-analysis stratified by surgery type, wound classification, antiseptic formulation, and country income, with meta-regression.

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Title: Chlorhexidine gluconate vs povidone-iodine for surgical site infection prevention: a systematic review and meta-analysis stratified by surgery type, wound classification, antiseptic formulation, and country income, with meta-regression.
Authors: Benhammou M; Faculty of Medicine, University of Oran 1, Ahmed Ben Bella, Oran, Algeria., Elraggal D; Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt., Saleh S; The Hashemite University, Zarqa, Jordan., Nobuhara CK; Department of Surgery, Stanford University, Stanford, CA, USA., van Ramshorst GH; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium; Department of Human Structure and Repair, Ghent University, Ghent, Belgium., Mimoz O; CHU de Poitiers, Service des Urgences Adultes-SAS 86-Centre 15, Poitiers, France; INSERM, U1070, Pharmacologie des Agents Anti-Infectieux, Poitiers, France; Alliance for Vascular Access Teaching and Research, Griffith University, Nathan, Queensland, Australia., Nounou MV; University of Nouakchott Al Aasrya, Faculty of Medicine, Nouakchott, Mauritania., Shawesh Q; Department of Internal Medicine, HCA Mountain View Hospital, Las Vegas, NV, USA., Tuuli MG; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, RI, USA., Wexner SD; Division of Colorectal Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Catena F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of General and Emergency Surgery Bufalini Hospital AUSL Romagna Cesena ITALY, Italy., Forrester JD; Department of Surgery, Stanford University, Stanford, CA, USA., Elhadi M; College of Medicine, Korea University, Seoul, South Korea. Electronic address: muhammed-elhadi@korea.ac.kr.
Source: The Journal of hospital infection [J Hosp Infect] 2026 Jul; Vol. 173, pp. 140-153. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Comparative Study; Review
Journal Info: Publisher: W.B. Saunders For The Hospital Infection Society Country of Publication: England NLM ID: 8007166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2939 (Electronic) Linking ISSN: 01956701 NLM ISO Abbreviation: J Hosp Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chlorhexidine gluconate vs povidone-iodine for surgical site infection prevention: a systematic review and meta-analysis stratified by surgery type, wound classification, antiseptic formulation, and country income, with meta-regression.
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  Data: <searchLink fieldCode="AU" term="%22Benhammou+M%22">Benhammou M</searchLink>; Faculty of Medicine, University of Oran 1, Ahmed Ben Bella, Oran, Algeria.<br /><searchLink fieldCode="AU" term="%22Elraggal+D%22">Elraggal D</searchLink>; Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt.<br /><searchLink fieldCode="AU" term="%22Saleh+S%22">Saleh S</searchLink>; The Hashemite University, Zarqa, Jordan.<br /><searchLink fieldCode="AU" term="%22Nobuhara+CK%22">Nobuhara CK</searchLink>; Department of Surgery, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22van+Ramshorst+GH%22">van Ramshorst GH</searchLink>; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Mimoz+O%22">Mimoz O</searchLink>; CHU de Poitiers, Service des Urgences Adultes-SAS 86-Centre 15, Poitiers, France; INSERM, U1070, Pharmacologie des Agents Anti-Infectieux, Poitiers, France; Alliance for Vascular Access Teaching and Research, Griffith University, Nathan, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Nounou+MV%22">Nounou MV</searchLink>; University of Nouakchott Al Aasrya, Faculty of Medicine, Nouakchott, Mauritania.<br /><searchLink fieldCode="AU" term="%22Shawesh+Q%22">Shawesh Q</searchLink>; Department of Internal Medicine, HCA Mountain View Hospital, Las Vegas, NV, USA.<br /><searchLink fieldCode="AU" term="%22Tuuli+MG%22">Tuuli MG</searchLink>; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Wexner+SD%22">Wexner SD</searchLink>; Division of Colorectal Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Catena+F%22">Catena F</searchLink>; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of General and Emergency Surgery Bufalini Hospital AUSL Romagna Cesena ITALY, Italy.<br /><searchLink fieldCode="AU" term="%22Forrester+JD%22">Forrester JD</searchLink>; Department of Surgery, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Elhadi+M%22">Elhadi M</searchLink>; College of Medicine, Korea University, Seoul, South Korea. Electronic address: muhammed-elhadi@korea.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%228007166%22">The Journal of hospital infection</searchLink> [J Hosp Infect] 2026 Jul; Vol. 173, pp. 140-153. <i>Date of Electronic Publication: </i>2026 Apr 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders+For+The+Hospital+Infection+Society%22">W.B. Saunders For The Hospital Infection Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8007166 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-2939 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201956701%22">01956701 </searchLink><i>NLM ISO Abbreviation: </i>J Hosp Infect <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jhin.2026.04.015
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              Text: 2026 Jul
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