Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 - PRODIGE 107 - FFCD 2306 - COLOSOTO trial.

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Title: Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 - PRODIGE 107 - FFCD 2306 - COLOSOTO trial.
Authors: Grancher A; Department of Hepato-Gastroenterology and Digestive Oncology, Rouen University Hospital, INSERM ANTICIPE U1086, Rouen, France., Landi M; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Ballhausen A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Vidal Tocino R; Department of Medical Oncology, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain., Alig A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Taravella A; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Le Malicot K; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France., Soularue E; Institut Mutualiste Montsouris, Service oncologie, Paris, France., Gallois C; Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris University, Paris, France., Guarssifi M; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France., Pelkowski M; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France., Beltran M; Grupo de Tratamiento de los Tumores Digestivos (TTD Group), Madrid, Spain., Kochen L; Frankfurter Institut für Klinische Krebsforschung (IKF), Frankfurt, Germany., Delliponti L; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Taïeb J; Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris University, Paris, France., Sastre J; Servicio de Oncologia Medical, Hospital Clínico San Carlos, 28040, Madrid, Spain., Modest DP; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Cremolini C; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Mazard T; Medical Oncology Department, Montpellier Cancer Institute (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, INSERM U1194, Montpellier, France., Tougeron D; Department of Hepatology and Gastroenterology, Poitiers University hospital and Poitiers university, Poitiers, France. Electronic address: david.tougeron@chu-poitiers.fr.
Source: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2026 Jul; Vol. 58 (7), pp. 966-972. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100958385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3562 (Electronic) Linking ISSN: 15908658 NLM ISO Abbreviation: Dig Liver Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-3562
DOI:10.1016/j.dld.2026.04.009