Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 - PRODIGE 107 - FFCD 2306 - COLOSOTO trial.
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| Title: | Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 - PRODIGE 107 - FFCD 2306 - COLOSOTO trial. |
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| Authors: | Grancher A; Department of Hepato-Gastroenterology and Digestive Oncology, Rouen University Hospital, INSERM ANTICIPE U1086, Rouen, France., Landi M; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Ballhausen A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Vidal Tocino R; Department of Medical Oncology, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain., Alig A; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Taravella A; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Le Malicot K; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France., Soularue E; Institut Mutualiste Montsouris, Service oncologie, Paris, France., Gallois C; Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris University, Paris, France., Guarssifi M; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France., Pelkowski M; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France., Beltran M; Grupo de Tratamiento de los Tumores Digestivos (TTD Group), Madrid, Spain., Kochen L; Frankfurter Institut für Klinische Krebsforschung (IKF), Frankfurt, Germany., Delliponti L; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Taïeb J; Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris University, Paris, France., Sastre J; Servicio de Oncologia Medical, Hospital Clínico San Carlos, 28040, Madrid, Spain., Modest DP; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany., Cremolini C; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Mazard T; Medical Oncology Department, Montpellier Cancer Institute (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, INSERM U1194, Montpellier, France., Tougeron D; Department of Hepatology and Gastroenterology, Poitiers University hospital and Poitiers university, Poitiers, France. Electronic address: david.tougeron@chu-poitiers.fr. |
| Source: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2026 Jul; Vol. 58 (7), pp. 966-972. Date of Electronic Publication: 2026 May 01. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100958385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3562 (Electronic) Linking ISSN: 15908658 NLM ISO Abbreviation: Dig Liver Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42069451 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 - PRODIGE 107 - FFCD 2306 - COLOSOTO trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Grancher+A%22">Grancher A</searchLink>; Department of Hepato-Gastroenterology and Digestive Oncology, Rouen University Hospital, INSERM ANTICIPE U1086, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Landi+M%22">Landi M</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Ballhausen+A%22">Ballhausen A</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Vidal+Tocino+R%22">Vidal Tocino R</searchLink>; Department of Medical Oncology, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Alig+A%22">Alig A</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Taravella+A%22">Taravella A</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Le+Malicot+K%22">Le Malicot K</searchLink>; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Soularue+E%22">Soularue E</searchLink>; Institut Mutualiste Montsouris, Service oncologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gallois+C%22">Gallois C</searchLink>; Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Guarssifi+M%22">Guarssifi M</searchLink>; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Pelkowski+M%22">Pelkowski M</searchLink>; Fédération Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, Faculté de Médecine, University of Burgundy and Franche Comté, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Beltran+M%22">Beltran M</searchLink>; Grupo de Tratamiento de los Tumores Digestivos (TTD Group), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Kochen+L%22">Kochen L</searchLink>; Frankfurter Institut für Klinische Krebsforschung (IKF), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Delliponti+L%22">Delliponti L</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Taïeb+J%22">Taïeb J</searchLink>; Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Université Paris-Cité, SIRIC CARPEM, Paris University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sastre+J%22">Sastre J</searchLink>; Servicio de Oncologia Medical, Hospital Clínico San Carlos, 28040, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Modest+DP%22">Modest DP</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Cremolini+C%22">Cremolini C</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Mazard+T%22">Mazard T</searchLink>; Medical Oncology Department, Montpellier Cancer Institute (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), University of Montpellier, INSERM U1194, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Tougeron+D%22">Tougeron D</searchLink>; Department of Hepatology and Gastroenterology, Poitiers University hospital and Poitiers university, Poitiers, France. Electronic address: david.tougeron@chu-poitiers.fr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100958385%22">Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver</searchLink> [Dig Liver Dis] 2026 Jul; Vol. 58 (7), pp. 966-972. <i>Date of Electronic Publication: </i>2026 May 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>100958385 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-3562 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215908658%22">15908658 </searchLink><i>NLM ISO Abbreviation: </i>Dig Liver Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42069451 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.dld.2026.04.009 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 966 Titles: – TitleFull: Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 - PRODIGE 107 - FFCD 2306 - COLOSOTO trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Grancher A – PersonEntity: Name: NameFull: Landi M – PersonEntity: Name: NameFull: Ballhausen A – PersonEntity: Name: NameFull: Vidal Tocino R – PersonEntity: Name: NameFull: Alig A – PersonEntity: Name: NameFull: Taravella A – PersonEntity: Name: NameFull: Le Malicot K – PersonEntity: Name: NameFull: Soularue E – PersonEntity: Name: NameFull: Gallois C – PersonEntity: Name: NameFull: Guarssifi M – PersonEntity: Name: NameFull: Pelkowski M – PersonEntity: Name: NameFull: Beltran M – PersonEntity: Name: NameFull: Kochen L – PersonEntity: Name: NameFull: Delliponti L – PersonEntity: Name: NameFull: Taïeb J – PersonEntity: Name: NameFull: Sastre J – PersonEntity: Name: NameFull: Modest DP – PersonEntity: Name: NameFull: Cremolini C – PersonEntity: Name: NameFull: Mazard T – PersonEntity: Name: NameFull: Tougeron D IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1878-3562 Numbering: – Type: volume Value: 58 – Type: issue Value: 7 Titles: – TitleFull: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Type: main |
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