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Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells.

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Title: Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells.
Authors: Xiao Y; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China., He M; Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China., Yao H; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China., Song Y; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.; Ministry of Education and Training of Children's Hospital Affiliated to Fudan University, Shanghai, China., Hu Y; Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun, China., Liu X; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China., Bai Y; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China., Zhang J; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China., Shao C; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China. clshao@shmu.edu.cn.; Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China. clshao@shmu.edu.cn., Pan Y; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China. swallowpan@fudan.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 May 03; Vol. 17 (1). Date of Electronic Publication: 2026 May 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Yao+H%22">Yao H</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.; Ministry of Education and Training of Children's Hospital Affiliated to Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Bai+Y%22">Bai Y</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shao+C%22">Shao C</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China. clshao@shmu.edu.cn.; Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China. clshao@shmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Pan+Y%22">Pan Y</searchLink>; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China. swallowpan@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 May 03; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 May 03
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