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Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study.

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Title: Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study.
Authors: Tang J; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Wang L; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China., Yang S; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.; Department of General Surgery, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, China., Peng W; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China., Zhang Y; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China., Zhang Y; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China., Jin K; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China., Wang X; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. wxw0213@njmu.edu.cn.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China. wxw0213@njmu.edu.cn.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. wxw0213@njmu.edu.cn., Feng Y; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. fengyifei1982@163.com.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China. fengyifei1982@163.com., Sun Y; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. sunyueming@njmu.edu.cn.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China. sunyueming@njmu.edu.cn.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. sunyueming@njmu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 04; Vol. 11 (1). Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.; Department of General Surgery, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, China.<br /><searchLink fieldCode="AU" term="%22Peng+W%22">Peng W</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Jin+K%22">Jin K</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. wxw0213@njmu.edu.cn.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China. wxw0213@njmu.edu.cn.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. wxw0213@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. fengyifei1982@163.com.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China. fengyifei1982@163.com.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Centre of Colorectum Cancer, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. sunyueming@njmu.edu.cn.; Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine, Nanjing, Jiangsu, China. sunyueming@njmu.edu.cn.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. sunyueming@njmu.edu.cn.
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        Value: 10.1038/s41392-026-02683-8
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        Text: English
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      – TitleFull: Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study.
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              Text: 2026 May 04
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