Reproductive history differentially shapes the neural response of middle-aged hAPOEɛ4 female rats to estradiol therapy after a metabolic challenge.

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Title: Reproductive history differentially shapes the neural response of middle-aged hAPOEɛ4 female rats to estradiol therapy after a metabolic challenge.
Authors: Richard JE; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Mohammad A; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada., Lieblich SE; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Go KA; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Wang S; Centre for Addiction and Mental Health, Toronto, ON, Canada., Rechlin RK; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Splinter TFL; Centre for Addiction and Mental Health, Toronto, ON, Canada., Barreto GE; Department of Biological Sciences, University of Limerick, Limerick, Ireland., Galea LAM; Centre for Addiction and Mental Health, Toronto, ON, Canada. liisa.galea@utoronto.ca.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. liisa.galea@utoronto.ca.; Institute of Medical Sciences, University of Toronto, Toronto, Canada. liisa.galea@utoronto.ca.; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. liisa.galea@utoronto.ca.; Department of Psychiatry, University of Toronto, Toronto, Canada. liisa.galea@utoronto.ca.
Source: Biology of sex differences [Biol Sex Differ] 2026 May 03; Vol. 17 (1). Date of Electronic Publication: 2026 May 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101548963 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-6410 (Electronic) Linking ISSN: 20426410 NLM ISO Abbreviation: Biol Sex Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2042-6410
DOI:10.1186/s13293-026-00911-y