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A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets.

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Title: A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets.
Authors: Gasser M; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada., Cherkaoui I; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada., Ostinelli G; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada., Ferron M; Institut de Recherche Clinique de Montréal and Department of Medicine, University of Montreal, Montreal, QC, Canada., Du Q; Columbia University, New York, NY, USA., Egli D; Columbia University, New York, NY, USA., Rutter GA; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom.; Lee Kong Chian School of Medicine, Nanyang Technological, University, Singapore, Singapore.; Research institute of the McGill University Health Sciences Centre, Montreal, QC, Canada.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Apr 20. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 42078397
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets.
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  Data: <searchLink fieldCode="AU" term="%22Gasser+M%22">Gasser M</searchLink>; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Cherkaoui+I%22">Cherkaoui I</searchLink>; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ostinelli+G%22">Ostinelli G</searchLink>; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ferron+M%22">Ferron M</searchLink>; Institut de Recherche Clinique de Montréal and Department of Medicine, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Du+Q%22">Du Q</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Egli+D%22">Egli D</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+GA%22">Rutter GA</searchLink>; Centre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom.; Lee Kong Chian School of Medicine, Nanyang Technological, University, Singapore, Singapore.; Research institute of the McGill University Health Sciences Centre, Montreal, QC, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Apr 20. <i>Date of Electronic Publication: </i>2026 Apr 20.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42078397
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        Value: 10.64898/2026.04.17.26351108
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        Text: English
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              Text: 2026 Apr 20
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