NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials.

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Title: NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials.
Authors: Zhou Y; Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China., Duan K; Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China., Luo S; Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China., Liu S; Department of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, China., Li Q; Department of Anesthesiology, Changsha Central Hospital, Changsha, China., Liu S; Department of Anesthesiology, Changsha Central Hospital, Changsha, China., Guo H; Department of Anesthesiology, The First People's Hospital of Changde, Changde, China., Jiang H; Department of Anesthesiology, Yueyang People's Hospital, Yueyang, China., Wang G; Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang H; Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang Z; Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Zhang X; Department of Anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Lianyungang, China., Sun C; Department of Anesthesiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China., Wang Q; Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Gao W; Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Shangguan W; Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China., Xia Z; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China., Luo A; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Chen C; Department of Anesthesiology, Yichang Central People's Hospital, Yichang, China., Yang M; Department of Anesthesiology, Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital (SAMSPH), Chengdu, China., Su W; Department of Anesthesiology, Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital (SAMSPH), Chengdu, China., Zou X; Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Li Y; Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China., Wang H; Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China., Huang Y; Department of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning Second People's Hospital, Nanning, Guangxi, China., Dai R; Department of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha, China., Zhao Q; Department of Anesthesiology, The Fourth Hospital of Changsha, Changsha, China., Jing S; Department of Anesthesiology, Jinan Central Hospital, Jinan, China., Zhang L; Department of Anesthesiology, The Second Hospital of Shanxi Medical University, Taiyuan, China., Yan W; Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, China., Qin X; Department of Anesthesiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Xinjiang, China., Wang J; Department of Anesthesiology, Huaibei Miner General Hospital, Huaibei, China., Chen J; Department of Anesthesiology, Wuhan Central Hospital, Wuhan, China., Cao J; Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang M; Department of Anesthesiology, Jiangxi Provincial People's Hospital, Nanchang, China., Yu S; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Ouyang W; Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China. ouyangwen139@126.com., Wang S; Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China. wsyxy3yy@csu.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 04; Vol. 17 (1). Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-72614-2