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5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.

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Title: 5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.
Authors: Cosentino C; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. cristina.cosentino@unil.ch., Klein R; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Menoud V; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Guay C; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Aiello E; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Auddino S; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Di Giuseppe G; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Ciccarelli G; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Galli A; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Alabiso F; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Mangano E; Institute for Biomedical Technologies, National Research Council, Milan, Italy., Brozzi F; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Bouzakri K; UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France., D'Adamo S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Cetrullo S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Istituto Nazionale per le Ricerche Cardiovascolari, Bologna, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy., Quero G; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Mari A; Institute of Neuroscience, National Research Council, Padua, Italy., Alfieri S; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Giaccari A; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Mezza T; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy., Dotta F; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Sebastiani G; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy., Regazzi R; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Source: Nature communications [Nat Commun] 2026 May 04; Vol. 17 (1). Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: 5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Cosentino+C%22">Cosentino C</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. cristina.cosentino@unil.ch.<br /><searchLink fieldCode="AU" term="%22Klein+R%22">Klein R</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Menoud+V%22">Menoud V</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guay+C%22">Guay C</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aiello+E%22">Aiello E</searchLink>; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Auddino+S%22">Auddino S</searchLink>; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giuseppe+G%22">Di Giuseppe G</searchLink>; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciccarelli+G%22">Ciccarelli G</searchLink>; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Galli+A%22">Galli A</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Alabiso+F%22">Alabiso F</searchLink>; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Mangano+E%22">Mangano E</searchLink>; Institute for Biomedical Technologies, National Research Council, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brozzi+F%22">Brozzi F</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bouzakri+K%22">Bouzakri K</searchLink>; UMR DIATHEC, EA 7294, Centre Européen d'Etude du Diabète, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22D'Adamo+S%22">D'Adamo S</searchLink>; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cetrullo+S%22">Cetrullo S</searchLink>; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Istituto Nazionale per le Ricerche Cardiovascolari, Bologna, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Quero+G%22">Quero G</searchLink>; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mari+A%22">Mari A</searchLink>; Institute of Neuroscience, National Research Council, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Alfieri+S%22">Alfieri S</searchLink>; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.; Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giaccari+A%22">Giaccari A</searchLink>; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mezza+T%22">Mezza T</searchLink>; Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Dotta+F%22">Dotta F</searchLink>; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Sebastiani+G%22">Sebastiani G</searchLink>; Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Regazzi+R%22">Regazzi R</searchLink>; Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 04; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 04.
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