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ASD mutations in the ciliary gene CEP41 impact development of projection neurons and interneurons in a human cortical organoid model.

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Title: ASD mutations in the ciliary gene CEP41 impact development of projection neurons and interneurons in a human cortical organoid model.
Authors: Hasenpusch-Theil K; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, United Kingdom.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, United Kingdom., Lesayova A; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, United Kingdom., Kozić Z; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, United Kingdom.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, United Kingdom., Beltran M; Institute for Regeneration & Repair (IRR), University of Edinburgh, Edinburgh Bioquarter, 4 - 7 Little France Drive, Edinburgh, EH16 4UU, United Kingdom., Wilson G; Institute for Regeneration & Repair (IRR), University of Edinburgh, Edinburgh Bioquarter, 4 - 7 Little France Drive, Edinburgh, EH16 4UU, United Kingdom., Henderson NC; Institute for Regeneration & Repair (IRR), University of Edinburgh, Edinburgh Bioquarter, 4 - 7 Little France Drive, Edinburgh, EH16 4UU, United Kingdom., Dando O; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, United Kingdom.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, United Kingdom., Theil T; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, United Kingdom. thomas.theil@ed.ac.uk.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh, EH8 9XD, United Kingdom. thomas.theil@ed.ac.uk.; Institute for Regeneration & Repair (IRR), University of Edinburgh, Edinburgh Bioquarter, 4 - 7 Little France Drive, Edinburgh, EH16 4UU, United Kingdom. thomas.theil@ed.ac.uk.
Source: Molecular psychiatry [Mol Psychiatry] 2026 May 04. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-026-03615-2