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Granulocyte differentiation arrest in HAX1-deficient cells, demonstrated in a new in vitro model of a certain phenotypic aspects of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake.

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Title: Granulocyte differentiation arrest in HAX1-deficient cells, demonstrated in a new in vitro model of a certain phenotypic aspects of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake.
Authors: Wakula M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Jablonowska M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Chmielarczyk M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Tarnowski L; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Kulinczak M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Sitkiewicz E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Swiderska B; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Samborowska E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Radkiewicz M; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Kianfar M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Statkiewicz M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Rumienczyk I; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Balcerak A; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Konopinski R; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Trebinska-Stryjewska A; Military University of Technology, Warsaw, Poland., Grzybowska EA; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. ewa.grzybowska@nio.gov.pl.
Source: Cell death & disease [Cell Death Dis] 2026 May 05; Vol. 17 (1). Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08805-y