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RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy.

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Title: RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy.
Authors: Rogge M; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany., Fischer J; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany., Jakobi T; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona, College of Medicine, Phoenix, USA., Loewenthal Z; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany., Gupta P; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany., Jürgensen L; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany., Frey N; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany., Sandmann C; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Völkers M; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.
Source: Journal of molecular and cellular cardiology plus [J Mol Cell Cardiol Plus] 2026 Apr 16; Vol. 16, pp. 100847. Date of Electronic Publication: 2026 Apr 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918470779706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-9761 (Electronic) Linking ISSN: 27729761 NLM ISO Abbreviation: J Mol Cell Cardiol Plus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy.
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  Data: <searchLink fieldCode="AU" term="%22Rogge+M%22">Rogge M</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+J%22">Fischer J</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jakobi+T%22">Jakobi T</searchLink>; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona, College of Medicine, Phoenix, USA.<br /><searchLink fieldCode="AU" term="%22Loewenthal+Z%22">Loewenthal Z</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gupta+P%22">Gupta P</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jürgensen+L%22">Jürgensen L</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Frey+N%22">Frey N</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sandmann+C%22">Sandmann C</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Völkers+M%22">Völkers M</searchLink>; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.
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  Data: <searchLink fieldCode="JN" term="%229918470779706676%22">Journal of molecular and cellular cardiology plus</searchLink> [J Mol Cell Cardiol Plus] 2026 Apr 16; Vol. 16, pp. 100847. <i>Date of Electronic Publication: </i>2026 Apr 16 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918470779706676 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2772-9761 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227729761%22">27729761 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Cardiol Plus <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.jmccpl.2026.100847
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              Text: 2026 Apr 16
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