Interface Architecture of a VHL-PROTAC Complex with and without Cullin-2.

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Bibliographic Details
Title: Interface Architecture of a VHL-PROTAC Complex with and without Cullin-2.
Authors: Whitford EN; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.; Native MS Guided Structural Biology Center, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Gilbert JD; Native MS Guided Structural Biology Center, The Ohio State University, Columbus, Ohio 43210, United States., Kostelic MM; Native MS Guided Structural Biology Center, The Ohio State University, Columbus, Ohio 43210, United States.; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States., Ehlinger AC; Target Enabling Technologies, AbbVie, 1 N. Waukegan Rd, North Chicago, Illinois 60064, United States., Thibaudeau TA; Target Enabling Technologies, AbbVie, 1 N. Waukegan Rd, North Chicago, Illinois 60064, United States., McLoughlin SM; Technology and Therapeutic Platforms, AbbVie, 1 N. Waukegan Rd, North Chicago, Illinois 60064, United States., Wysocki VH; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.; Native MS Guided Structural Biology Center, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 May 20; Vol. 148 (19), pp. 19730-19737. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5126
DOI:10.1021/jacs.6c01509