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Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.

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Title: Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.
Authors: Han F; Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (F.H., Y.-C.Z.)., Clancy U; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Arteaga-Reyes C; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Thrippleton MJ; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Valdés Hernández MDC; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Jaime Garcia D; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Stringer MS; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Backhouse E; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Chappell FM; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Cheng Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu (Y.C.)., Liu DX; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco (D.X.L.)., Zhang J; Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China (J.F.)., Jochems ACC; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Sakka E; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Jardine C; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., Barclay G; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., McIntyre D; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., Hamilton I; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., Brown R; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Zhu YC; Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (F.H., Y.-C.Z.)., Doubal FN; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Wardlaw JM; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).
Source: Circulation [Circulation] 2026 Jun 09; Vol. 153 (23), pp. 1813-1826. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.
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UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Thrippleton+MJ%22">Thrippleton MJ</searchLink>; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Valdés+Hernández+MDC%22">Valdés Hernández MDC</searchLink>; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Jaime+Garcia+D%22">Jaime Garcia D</searchLink>; 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UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Chappell+FM%22">Chappell FM</searchLink>; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Cheng+Y%22">Cheng Y</searchLink>; Department of Neurology, West China Hospital, Sichuan University, Chengdu (Y.C.).<br /><searchLink fieldCode="AU" term="%22Liu+DX%22">Liu DX</searchLink>; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco (D.X.L.).<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China (J.F.).<br /><searchLink fieldCode="AU" term="%22Jochems+ACC%22">Jochems ACC</searchLink>; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Sakka+E%22">Sakka E</searchLink>; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Jardine+C%22">Jardine C</searchLink>; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.).<br /><searchLink fieldCode="AU" term="%22Barclay+G%22">Barclay G</searchLink>; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.).<br /><searchLink fieldCode="AU" term="%22McIntyre+D%22">McIntyre D</searchLink>; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.).<br /><searchLink fieldCode="AU" term="%22Hamilton+I%22">Hamilton I</searchLink>; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.).<br /><searchLink fieldCode="AU" term="%22Brown+R%22">Brown R</searchLink>; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).<br /><searchLink fieldCode="AU" term="%22Zhu+YC%22">Zhu YC</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%220147763%22">Circulation</searchLink> [Circulation] 2026 Jun 09; Vol. 153 (23), pp. 1813-1826. <i>Date of Electronic Publication: </i>2026 May 06.
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      – TitleFull: Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.
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          Name:
            NameFull: Doubal FN
      – PersonEntity:
          Name:
            NameFull: Wardlaw JM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 06
              Text: 2026 Jun 09
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1524-4539
          Numbering:
            – Type: volume
              Value: 153
            – Type: issue
              Value: 23
          Titles:
            – TitleFull: Circulation
              Type: main
ResultId 1